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Critical Streptococcus suis Virulence Factors: Are They All Really Critical?
Trends in Microbiology ( IF 15.9 ) Pub Date : 2017-03-06 , DOI: 10.1016/j.tim.2017.02.005
Mariela Segura , Nahuel Fittipaldi , Cynthia Calzas , Marcelo Gottschalk

Streptococcus suis is an important swine pathogen that can be transmitted to humans by contact with diseased animals or contaminated raw pork products. This pathogen possesses a coat of capsular polysaccharide (CPS) that confers protection against the immune system. Yet, the CPS is not the only virulence factor enabling this bacterium to successfully colonize, invade, and disseminate in its host leading to severe systemic diseases such as meningitis and toxic shock-like syndrome. Indeed, recent research developments, cautiously inventoried in this review, have revealed over 100 ‘putative virulence factors or traits’ (surface-associated or secreted components, regulatory genes or metabolic pathways), of which at least 37 have been claimed as being ‘critical’ for virulence. In this review we discuss the current contradictions and controversies raised by this explosion of virulence factors and the future directions that may be conceived to advance and enlighten research on S. suis pathogenesis.



中文翻译:

严重链球菌致病因素:它们都真的很重要吗?

猪链球菌是重要的猪病原体,可通过与患病动物或受污染的生猪肉产品接触而传播给人类。这种病原体具有一层荚膜多糖(CPS),可赋予抵抗免疫系统的保护。然而,CPS并不是使该细菌成功定殖,侵入并在其宿主中传播的唯一致病因子,从而导致严重的系统性疾病,例如脑膜炎和中毒性休克样综合症。确实,在此综述中谨慎地盘点了最近的研究进展,发现了100多种“潜在毒力因子或性状”(表面相关或分泌的成分,调节基因或代谢途径),其中至少37种被认为是“关键” '的毒力。猪链球菌的发病机理。

更新日期:2017-03-06
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