Many mammalian species, including humans, exhibit social behavior and form complex social groups. Mechanistic studies in animal models have revealed important roles for the endocannabinoid signaling system, comprising G protein-coupled cannabinoid receptors and their endogenous lipid-derived agonists, in the control of neural processes that underpin social anxiety and social reward, two key aspects of social behavior. An emergent insight from these studies is that endocannabinoid signaling in specific circuits of the brain is context dependent and selectively recruited. These insights open new vistas on the neural basis of social behavior and social impairment.

中文翻译：

---

控制社会行为的内源性大麻素信号

许多哺乳动物物种，包括人类，表现出社会行为并形成复杂的社会群体。动物模型的机制研究揭示了内源性大麻素信号系统的重要作用，包括 G 蛋白偶联大麻素受体及其内源性脂质衍生激动剂，在控制支持社交焦虑和社交奖励的神经过程中的重要作用，这是社交行为的两个关键方面. 从这些研究中得出的一个新见解是，大脑特定回路中的内源性大麻素信号是依赖于环境的，并且是选择性招募的。这些见解为社会行为和社会障碍的神经基础开辟了新的视野。