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Monoamine Transporters as Ionotropic Receptors
Trends in Neurosciences ( IF 15.9 ) Pub Date : 2017-04-01 , DOI: 10.1016/j.tins.2017.02.003
Louis J. De Felice

It is well established that glutamate and GABA signal through both ionotropic and metabotropic receptors. Conversely, it is thought that, with one exception, monoamines (dopamine, serotonin, and norepinephrine) signal via metabotropic receptors. Given their capacity to generate fast-acting currents, I suggest that the monoamine transporters should be considered as ionotropic receptors.

中文翻译:

作为离子型受体的单胺转运蛋白

众所周知,谷氨酸和 GABA 通过离子型和代谢型受体发出信号。相反,人们认为,单胺(多巴胺、血清素和去甲肾上腺素)通过代谢型受体发出信号,但有一个例外。鉴于它们产生快速作用电流的能力,我建议应将单胺转运蛋白视为离子型受体。
更新日期:2017-04-01
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