Mechanistic models require a significant investment of time and resources, but their application to multiple stages of fermentation process development and operation can make this investment highly valuable. This Opinion article discusses how an established fermentation model may be adapted for application to different stages of fermentation process development: planning, process design, monitoring, and control. Although a longer development time is required for such modeling methods in comparison to purely data-based model techniques, the wide range of applications makes them a highly valuable tool for fermentation research and development. In addition, in a research environment, where collaboration is important, developing mechanistic models provides a platform for knowledge sharing and consolidation of existing process understanding.

机械模型需要大量的时间和资源投资，但是将其应用于发酵过程开发和操作的多个阶段可以使这项投资具有很高的价值。本意见文章讨论了如何将已建立的发酵模型改编为应用于发酵过程开发的不同阶段：计划，过程设计，监控和控制。尽管与纯粹基于数据的建模技术相比，此类建模方法需要更长的开发时间，但广泛的应用使其成为发酵研究和开发的极有价值的工具。此外，在协作非常重要的研究环境中，开发机械模型可以提供知识共享和巩固现有过程理解的平台。