The biophysical properties of cellular membranes intimately influence the delivery of cargoes into cells by cell-penetrating peptides (CPPs) and the bactericidal activity of antimicrobial peptides (AMPs). Here, we discuss how lipid oxidation creates important chemical and biophysical changes in membranes, and hypothesize about the observed synergy between oxidized membranes and membrane-active peptides.

中文翻译：

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膜氧化如何影响细胞传递和细胞杀伤？

细胞膜的生物物理特性通过细胞穿透肽（CPPs）和抗菌肽（AMPs）的杀菌活性密切影响货物向细胞内的传递。在这里，我们讨论脂质氧化如何在膜上产生重要的化学和生物物理变化，并假设关于氧化膜和膜活性肽之间观察到的协同作用。