Reconstructing functional skin after a wound remains a challenge due to the complexity of healing. In this regard, biocompatible nanoparticles (NPs) carrying and releasing bioactive drugs in a controlled and sustained manner may significantly improve the efficacy of wound therapies compared with current treatments. Topical administration of drug-loaded NPs allows optimal delivery to the dermis and improves product efficacy. Furthermore, associating NPs with scaffolds represents a new concept of ‘dressing’. Experimental in vivo, ex vivo, and in vitro models have been developed in preclinical assays to evaluate the beneficial effects of nanoparticulate dressings. Drug-loaded NPs are promising tools for innovative wound healing treatment, especially with regard to their multifunctional properties.

由于愈合的复杂性，在伤口后重建功能性皮肤仍然是一个挑战。在这方面，与目前的治疗相比，以受控和持续的方式携带和释放生物活性药物的生物相容性纳米颗粒（NPs）可以显着改善伤口疗法的功效。局部给药载药的NP可以最佳地递送至真皮并提高产品功效。此外，将NP与支架相关联代表了“穿戴”的新概念。实验在体内，离体，和体外在临床前测定中开发了模型，以评估纳米颗粒敷料的有益作用。载有药物的NP是创新伤口愈合治疗的有前途的工具，尤其是在其多功能特性方面。