The cytochrome P450 monooxygenase system (CYP) is a multigene superfamily of enzymes, which are important in the metabolism of foreign and endogenous compounds. CYP isoforms metabolize a number of n-3 and n-6 polyunsaturated fatty acids (PUFA), including linoleic acid (18:2n6, LA), arachidonic acid (20:4n6, AA), ecosapentaenoic acid (20:5n3, EPA) and docosahexaenoic acid (22:6n3, DHA) into bioactive lipid mediators, termed eicosanoids. CYP-derived eicosanoids have numerous effects toward physiological and pathophysiological events within the body, which depends on the type, quantity and timing of metabolites produced. Alterations in fatty acid composition and concentrations have been shown to have a role in cardiovascular disease (CVD). The functional role of CYP isozymes and CYP-derived eicosanoids toward physiological and pathophysiological processes in the heart is a rapidly expanding field of research. Numerous studies have investigated the beneficial and detrimental effects of CYP epoxygenase derived metabolites of AA, epoxyeicosatrienoic acids (EET) and CYP ω-hydroxylase products, hydroxyeicosatetraenoic acids (HETE), toward both cardiac and vascular function and disease. Emerging research is revealing the importance of other lipid mediators generated from CYP isozymes, such as epoxyeicosatetraenoic acids (EEQ) and epoxydocosapentaenoic acids (EDP), formed from the metabolism of EPA and DHA and metabolites of LA. Important determinants such as genetics, gender and age have a role in regulating the CYP-derived eicosanoids produced from the metabolism n-3 and n-6 PUFA. Obtaining a better understanding of the complex role CYP-derived eicosanoids have within the heart will provide valuable insight for both basic and clinical researchers investigation CVD.

细胞色素P450单加氧酶系统（CYP）是酶的多基因超家族，在外源和内源性化合物的代谢中很重要。CYP亚型可代谢多种n-3和n-6多不饱和脂肪酸（PUFA），包括亚油酸（18：2n6，LA），花生四烯酸（20：4n6，AA），二十碳五烯酸（20：5n3，EPA）和二十二碳六烯酸（22：6n3，DHA）转化为生物活性脂质介质，称为类花生酸。CYP衍生的类花生酸对体内的生理和病理生理事件具有多种作用，这取决于所产生代谢产物的类型，数量和时间。脂肪酸组成和浓度的变化已显示在心血管疾病（CVD）中起作用。CYP同工酶和CYP衍生的类花生酸对心脏的生理和病理生理过程的功能作用是一个迅速扩展的研究领域。许多研究已经研究了CYP氧化酶衍生的AA代谢产物，环氧二十碳三烯酸（EET）和CYPω-羟化酶产物，羟基二十碳四烯酸（HETE）对心脏和血管功能以及疾病的有益和有害作用。新兴研究揭示了由CYP同工酶产生的其他脂质介体的重要性，例如由EPA和DHA的代谢以及LA的代谢产物形成的环氧二十碳四烯酸（EEQ）和环氧二十碳五烯酸（EDP）。重要的决定因素，例如遗传学，性别和年龄，在调节由n-3和n-6 PUFA代谢产生的CYP衍生类花生酸中起作用。