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The application of optical coherence tomography angiography in uveitis and inflammatory eye diseases
Progress in Retinal and Eye Research ( IF 17.8 ) Pub Date : 2017-04-29 , DOI: 10.1016/j.preteyeres.2017.04.005
Francesco Pichi , David Sarraf , Sruthi Arepalli , Careen Y. Lowder , Emmett T. Cunningham , Piergiorgio Neri , Thomas A. Albini , Vishali Gupta , Kimberly Baynes , Sunil K. Srivastava

Since its introduction in the early 1990s, optical coherence tomography (OCT) has evolved in resolution and technological advances, and in recent years its initial application of assessing the morphology of a tissue has been implemented by the study of its functional blood flow, through optical coherence tomography angiography (OCTA). This novel technique details capillary networks by comparing the amount of light returned from static and moving targets without the need for intravenous dye administration. While this imaging modality has been used for various ocular conditions, the application OCTA to uveitis conditions remains sparse.

This review aims to establish the basis of OCTA and its current application to ocular inflammatory disorders, with an emphasis on monitoring progression and response to treatment, as well as predicting visual complications. In particular, this review explores the use of OCTA in iris vessel dilation seen in various forms of iritis, as a predictive factor for further episodes of inflammation. OCTA can also depict ischemia in the deep plexus layers of the retina and identify true choroicapillaris ischemia in cases of placoid diseases or masking of the indocyanine green dye, as in multiple evanescent white dot syndrome. In addition, OCTA can depict neovascularization in granulomatous disease of the retina or choroid not previously depicted with previous imaging methods. While OCTA provides several advancements in the imaging, management and prognosis of uveitis diseases, we emphasize that further studies are required to fully understand its application to these conditions.



中文翻译:

光学相干断层扫描血管造影在葡萄膜炎和炎性眼病中的应用

自1990年代初期引入光学相干断层扫描(OCT)以来,它在分辨率和技术发展方面都在发展,近年来,通过对组织功能血流的研究,通过光学方法实现了其最初用于评估组织形态的应用相干断层扫描血管造影(OCTA)。这项新技术通过比较静态目标和移动目标返回的光量来详细描述毛细管网络,而无需静脉内施用染料。尽管这种成像方式已用于各种眼部疾病,但将OCTA应用于葡萄膜炎的情况仍然很少。

这篇综述旨在建立OCTA的基础及其当前在眼部炎症性疾病中的应用,重点是监测治疗的进展和对治疗的反应,以及预测视觉并发症。特别是,本综述探讨了以各种形式的虹膜炎所见,在虹膜血管扩张中使用OCTA的情况,将其作为炎症进一步发作的预测因素。OCTA还可以描绘视网膜深丛丛中的局部缺血,并在类冰川期疾病或吲哚菁绿染料掩盖的情况下,如在多个van逝性白点综合征中,鉴定出真正的脉络膜胆囊炎局部缺血。此外,OCTA可以描绘以前未使用以前的成像方法描绘的视网膜或脉络膜肉芽肿性疾病中的新血管形成。尽管OCTA在成像方面取得了一些进步,

更新日期:2017-04-29
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