Retinal degenerative diseases are a leading cause of irreversible blindness and visual impairment, affecting millions of people worldwide. Although intravitreal injection can directly deliver drugs to the posterior segment of the eye, it is invasive and associated with serious side effects. The design of drug delivery systems targeting the posterior segment of the eye in a less invasive manner has still been challenging because of various anatomical and physiological barriers. In this review, we provide an overview of the current implant device-based approaches used for treating retinal degenerative diseases. We then offer our perspectives on future directions and challenges that remain for developing more effective device-based therapies for retinal diseases.

视网膜退行性疾病是不可逆性失明和视力障碍的主要原因，影响着全球数百万人。尽管玻璃体内注射可以直接将药物输送到眼后段，但它具有侵入性，并伴有严重的副作用。由于各种解剖学和生理学的障碍，以侵入性较小的方式瞄准眼后段的药物输送系统的设计仍然具有挑战性。在这篇综述中，我们提供了用于治疗视网膜退行性疾病的当前基于植入设备的方法的概述。然后，我们就开发针对视网膜疾病的更有效的基于设备的疗法的未来方向和挑战提出了自己的观点。