Hepatocellular adenomas (HCA) are rare benign liver tumors occurring in young women taking contraception. They are associated with rare complications such as bleeding or malignant transformation into hepatocellular carcinoma. A molecular classification has divided HCA in several subgroups linked with risk factors, clinical behaviour, histological features and imaging: HNF1A inactivated HCA, Inflammatory HCA, CTNNB1 mutated HCA in exon 3, CTNNB1 mutated in exon 7 and 8 HCA, sonic hedgehog HCA and unclassified HCA. CTNNB1 mutated HCA in exon 3 and sonic hedgehog HCA have been linked with a high risk of malignant transformation and bleeding respectively. Herein, we review how molecular classification has modified our understanding of the pathophysiology and risk factors of HCA development, analysing its impact on clinical care in the field of diagnosis and therapeutic stratification.

中文翻译：

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肝细胞腺瘤临床分子分型

肝细胞腺瘤 (HCA) 是一种罕见的良性肝脏肿瘤，发生在采取避孕措施的年轻女性中。它们与罕见的并发症有关，例如出血或恶性转化为肝细胞癌。分子分类已将 HCA 分为几个与危险因素、临床行为、组织学特征和影像学相关的亚组：HNF1A 灭活 HCA、炎性 HCA、CTNNB1 外显子 3 中的 HCA 突变、CTNNB1 外显子 7 和 8 HCA 中的突变、声波刺猬 HCA 和未分类HCA。CTNNB1 外显子 3 中的 HCA 突变和声波刺猬 HCA 分别与恶性转化和出血的高风险有关。在此，我们回顾了分子分类如何改变了我们对 HCA 发展的病理生理学和危险因素的理解，