Activating nuclear factor erythroid 2 (NF-E2)-related factor (Nrf2) is a widely recognized strategy for combating oxidative-stress-induced diseases. However, Nrf2 activation does not always bring advantageous effects. Therefore, before performing Nrf2-targeted therapy, we must pinpoint whether Nrf2 should be activated or inhibited.

中文翻译：

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激活还是抑制Nrf2？

激活核因子类红细胞2（NF-E2）相关因子（Nrf2）是对抗氧化应激诱发疾病的广泛认可的策略。但是，Nrf2激活并不总是能带来有利的影响。因此，在进行Nrf2靶向治疗之前，我们必须指出是否应激活或抑制Nrf2。