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Roles of Diacylglycerols and Ceramides in Hepatic Insulin Resistance
Trends in Pharmacological Sciences ( IF 13.8 ) Pub Date : 2017-05-24 , DOI: 10.1016/j.tips.2017.04.004
Max C Petersen 1 , Gerald I Shulman 2
Affiliation  

Although ample evidence links hepatic lipid accumulation with hepatic insulin resistance, the mechanistic basis of this association is incompletely understood and controversial. Diacylglycerols (DAGs) and ceramides have emerged as the two best-studied putative mediators of lipid-induced hepatic insulin resistance. Both lipids were first associated with insulin resistance in skeletal muscle and were subsequently hypothesized to mediate insulin resistance in the liver. However, the putative roles for DAGs and ceramides in hepatic insulin resistance have proved more complex than originally imagined, with various genetic and pharmacologic manipulations yielding a vast and occasionally contradictory trove of data to sort. In this review we examine the state of this field, turning a critical eye toward both DAGs and ceramides as putative mediators of lipid-induced hepatic insulin resistance.



中文翻译:

二酰基甘油和神经酰胺在肝胰岛素抵抗中的作用

尽管有充分的证据将肝脏脂质积累与肝脏胰岛素抵抗联系起来,但这种关联的机制基础尚不完全清楚且存在争议。二酰基甘油 (DAG) 和神经酰胺已成为脂质诱导的肝胰岛素抵抗的两种研究最充分的假定介质。这两种脂质首先与骨骼肌中的胰岛素抵抗有关,随后被假设介导肝脏中的胰岛素抵抗。然而,事实证明,DAG 和神经酰胺在肝胰岛素抵抗中的假定作用比最初想象的要复杂得多,各种遗传和药理学操作产生了大量且有时相互矛盾的数据进行分类。在这篇评论中,我们检查了该领域的状况,

更新日期:2017-05-24
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