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How Active Mechanics and Regulatory Biochemistry Combine to Form Patterns in Development
Annual Review of Biophysics ( IF 12.4 ) Pub Date : 2017-05-22 00:00:00 , DOI: 10.1146/annurev-biophys-070816-033602
Peter Gross 1, 2, 3 , K. Vijay Kumar 4 , Stephan W. Grill 1, 2, 3
Affiliation  

The development of organisms starting from their zygotic state involves a tight integration of the myriad biochemical signaling interactions with the mechanical forces that eventually pattern and shape the resulting embryo. In the past decade, it has become increasingly evident that several important developmental processes involve mechanical forces in an essential manner. In this review, we highlight the multifaceted role of mechanics in pattern formation, from protein and cell sorting to the generation of tissue shape. We then review the ways in which the active cellular cytoskeleton self-organizes to form dynamic patterns. Finally, we focus on mechanochemical feedback, where signaling proteins can establish patterns via coupling to the activity of the cytoskeleton. Throughout the review, we focus on the generic physical principles of the establishment of active mechanochemical patterns and point toward future directions in studying how the principles of mechanics and chemistry combine to drive morphogenetic pattern formation.

中文翻译:


主动力学与调控生物化学如何结合形成发展模式

从合子状态开始的生物体的发展涉及无数生化信号相互作用与最终形成图案并塑造最终胚胎的机械力的紧密结合。在过去的十年中,越来越重要的是,几个重要的发展过程以必不可少的方式涉及机械力。在这篇综述中,我们强调了机制在模式形成中的多方面作用,从蛋白质和细胞分选到组织形状的产生。然后,我们回顾了主动细胞骨架自我组织以形成动态模式的方式。最后,我们集中在机械化学反馈上,其中信号蛋白可以通过与细胞骨架的活性偶联来建立模式。在整个审核过程中,

更新日期:2017-05-22
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