当前位置: X-MOL 学术Annu. Rev. Biophys. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Geometric Principles for Designing Highly Symmetric Self-Assembling Protein Nanomaterials
Annual Review of Biophysics ( IF 12.4 ) Pub Date : 2017-05-22 00:00:00 , DOI: 10.1146/annurev-biophys-070816-033928
Todd O. Yeates 1, 2
Affiliation  

Emerging protein design strategies are enabling the creation of diverse, self-assembling supramolecular structures with precision on the atomic scale. The design possibilities include various types of architectures: finite cages or shells, essentially unbounded two-dimensional and three-dimensional arrays (i.e., crystals), and linear or tubular filaments. In nature, structures of those types are generally symmetric, and, accordingly, symmetry provides a powerful guide for developing new design approaches. Recent design studies have produced numerous protein assemblies in close agreement with geometric specifications. For certain design approaches, a complete list of allowable symmetry combinations that can be used for construction has been articulated, opening a path to a rich diversity of geometrically defined protein materials. Future challenges include improving and elaborating on current strategies and endowing designed protein nanomaterials with properties useful in nanomedicine and material science applications.

中文翻译:


设计高度对称的自组装蛋白纳米材料的几何原理

新兴的蛋白质设计策略使人们能够精确地在原子尺度上创建多样的,自组装的超分子结构。设计可能性包括各种类型的体系结构:有限的笼子或外壳,基本上无界的二维和三维阵列(即晶体)以及线性或管状细丝。实际上,这些类型的结构通常是对称的,因此,对称性为开发新的设计方法提供了有力的指导。最近的设计研究已经产生了许多与几何规格非常吻合的蛋白质组装体。对于某些设计方法,已经阐明了可用于构建的可允许的对称组合的完整列表,从而开辟了通往丰富多样的几何定义蛋白质材料的道路。

更新日期:2017-05-22
down
wechat
bug