Near-infrared photoimmunotherapy (NIR-PIT) is a new cancer treatment that combines the specificity of antibodies for targeting tumors with toxicity induced by photoabsorbers after irradiation with NIR light. A limitation of NIR-PIT is the inability to deliver NIR light to a tumor located deep inside the body. Cerenkov radiation (CR) is the ultraviolet and blue light that is produced by a charged particle traveling through a dielectric medium faster than the speed of light in that medium and is commonly produced during radioactive decay. Here, we demonstrate the feasibility of using CR generated by ¹⁸F-FDG accumulated in tumors to induce photoimmunotherapy. Methods: Using A431-luc cells, we evaluated the therapeutic effects of CR-PIT in vitro and in vivo using bioluminescence imaging. Results: CR-PIT showed significant suppression of tumor size, but the decrease of bioluminescence after CR-PIT was not observed consistently over the entire time course. Conclusion: Although CR-PIT can induce tumor killing deep within body, it is less effective than NIR-PIT, possibly related to the relatively lower efficiency of short wavelength light than NIR.

近红外光免疫疗法（NIR-PIT）是一种新的癌症治疗方法，结合了靶向肿瘤的抗体的特异性和近红外光照射后由光吸收剂诱导的毒性。NIR-PIT的局限性是无法将NIR光传递到体内深处的肿瘤。切伦科夫辐射（CR）是紫外线和蓝光，它是由带电粒子在电介质中传播的速度快于该介质中光速而产生的，通常是在放射性衰变过程中产生的。在这里，我们证明了使用由¹⁸ F-FDG累积在肿瘤中产生的CR诱导光免疫疗法的可行性。方法：使用A431-luc细胞，我们使用生物发光成像技术评估了CR-PIT在体外和体内的治疗效果。结果： CR-PIT表现出对肿瘤大小的显着抑制，但是在整个时间过程中并未始终观察到CR-PIT后生物发光的减少。结论：尽管CR-PIT可以诱导体内深处的肿瘤杀伤，但其效果不如NIR-PIT，可能与短波长光的效率相对于NIR较低有关。