Laser Desorption Ionization Mass Spectrometry (LDI MS), has grown in popularity solving the matrix interference problem that Matrix assisted Laser Desorption Ionization Mass Spectrometry (MALDI MS) faced. The silicon based nanostructure LDI platforms have manifested with hypes and spikes, yet have already started showing signs of premature decay or stagnation. Nanopost Array Laser Desorption Ionization Mass Spectrometry (NAPA LDI), the latest generation of the LDI variants has surfaced with an ability to overcome other LDI MS limitations. But, it is still confined within not more than tens of researchers. When MALDI MS has flourished inspite of the varied limitations; the slowing down of this technique inspite of no disclosed limitation, is what prompted this review. The current loss of enthusiasm with respect to this technique and the reasons behind the obvious lack of popularity inspite of this technique’s versatility are speculated.

中文翻译：

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纳米柱阵列激光解吸电离质谱（NAPA-LDI MS）：聚集青苔吗？

激光解吸电离质谱法（LDI MS）在解决基质辅助激光解吸电离质谱法（MALDI MS）面临的基质干扰问题方面日益普及。基于硅的纳米结构LDI平台表现出炒作和尖峰，但已经开始显示过早衰落或停滞的迹象。纳米柱阵列激光解吸电离质谱（NAPA LDI）是最新一代的LDI变体，具有克服其他LDI MS局限性的能力。但是，它仍然局限于不超过数十名研究人员之内。尽管存在各种局限性，但MALDI MS蓬勃发展时；尽管没有公开的限制，但这项技术的放慢是促使本次审查的原因。