AbstractThe authors describe a voltammetric method for the simultaneous determination of acetaminophen (ACOP) and caffeine (CAF) using a glassy carbon electrode modified with a Nafion® protected halloysite nanotubular clay (GCE). Enhanced electrocatalytic oxidation behavior was observed at pH 4.5 in acetate buffer medium, with oxidation peak potentials of + 0.21 V for ACOP and + 1.0 V for CAF. The peak potential window (~ 800 mV) is quite large and hence differential pulse voltammetry (DPV) can be applied for simultaneous determination of both analytes. The calibration plots of ACOP and CAF are linear in the concentration ranges from 0.6 μM to 14 μM and 0.6 μM to 20 μM, and the detection limits are 1.1 × 10−8 M and 1.73 × 10−7 M, for ACOP and CAF, respectively. The method was applied to the determination of both analytes in drug formulations and human urine samples. Graphical abstractSchematic of a mediator-free voltammetric method for the simultaneous determination of acetaminophen and caffeine using glassy carbon electrode modified with a Nafion® protected halloysite nanotubular clay

中文翻译：

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使用纳米管粘土修饰的玻碳电极同时测定对乙酰氨基酚和咖啡因的无介体

摘要作者描述了一种使用经 Nafion® 保护的埃洛石纳米管状粘土 (GCE) 修饰的玻碳电极同时测定对乙酰氨基酚 (ACOP) 和咖啡因 (CAF) 的伏安法。在醋酸盐缓冲介质中，在 pH 值为 4.5 时观察到电催化氧化行为增强，ACOP 的氧化峰电位为 + 0.21 V，CAF 的氧化峰电位为 + 1.0 V。峰值电位窗口 (~ 800 mV) 非常大，因此差分脉冲伏安法 (DPV) 可用于同时测定两种分析物。ACOP 和 CAF 的校准曲线在 0.6 μM 至 14 μM 和 0.6 μM 至 20 μM 的浓度范围内呈线性，检测限分别为 1.1 × 10−8 M 和 1.73 × 10−7 M，对于 ACOP 和 CAF，分别。该方法用于测定药物制剂和人体尿液样品中的分析物。图形摘要使用经 Nafion® 保护的埃洛石纳米管粘土改性的玻碳电极同时测定对乙酰氨基酚和咖啡因的无介体伏安法示意图