The ease of separation, simple regeneration, and the usually high stability of solid catalysts facilitating continuous production processes have stimulated the development of heterogeneous asymmetric hydrogenation catalysis. The simplest and so far most promising strategy to induce enantioselectivity to solid metal catalysts is their modification by chiral organic compounds, as most prominently represented by the cinchona-modified Pt and Pd catalysts for the asymmetric hydrogenation of activated C═O and C═C bonds. In this Review, we provide a systematic account of the research accomplished in the past decade on noble metal-based heterogeneous asymmetric hydrogenation of prochiral C═O and C═C bonds, including all important facets of these catalytic systems. The advances made are critically analyzed, and future research challenges are identified.

中文翻译：

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负载贵金属催化剂上C═O和C═C键的非均相不对称加氢新进展

分离的容易性，简单的再生以及固体催化剂通常的高稳定性有利于连续生产过程，这刺激了非均相不对称氢化催化的发展。诱导对固态金属催化剂的对映选择性的最简单，也是迄今为止最有希望的策略是通过手性有机化合物对其进行改性，最突出的是由金鸡纳改性的Pt和Pd催化剂对活化的C═O和C═C键进行不对称氢化。在这篇综述中，我们对过去十年中基于贵金属的前手性C═O和C═C键的异质不对称加氢研究，包括这些催化体系的所有重要方面，进行了系统的介绍。我们对所取得的进展进行了严格的分析，并确定了未来的研究挑战。