In Reply We welcome this opportunity to make some clarifications, and to direct readers to previous publications that address many of the concerns raised by Zhang et al.

There has been substantial interest from the scientific community in a complete picture of the net balance of benefits and harms of intensive blood pressure control.¹ Because physical function represents one component of this evaluation, our study² examined changes in gait speed in the subgroup of SPRINT participants 75 years or older at baseline.³ While procedures for the measurement of gait speed were specified in the SPRINT protocol, the authors are correct that gait speed and mobility limitation were not prespecified as outcomes in the protocol or on clinicaltrials.gov. However, gait speed is well-established, well-accepted measure of physical function, and so we reject any allusion that there was selective reporting of the outcomes in our study.²

在答复中我们欢迎有这样的机会进行澄清，并引导读者进入以前的出版物，这些出版物解决了Zhang等人提出的许多问题。

全面了解强化血压控制的利弊净平衡引起了科学界的极大兴趣。¹因为身体机能是该评估的一个组成部分，所以我们的研究²在基线时检查了75岁或75岁以上SPRINT参与者亚组的步态速度变化。³虽然在SPRINT协议中指定了步态速度的测量程序，但作者们正确的认为，在协议或临床试验.gov中未将步态速度和活动性限制预先指定为结果。但是，步态速度是公认的，公认的身体机能指标，因此我们不接受任何关于在研究中选择性报告结局的说法。^2个