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Toxicological effects of patulin mycotoxin on the mammalian system: an overview
Toxicology Research ( IF 2.1 ) Pub Date : 2017-08-09 00:00:00 , DOI: 10.1039/c7tx00138j
Saurabh Pal 1, 2 , Neha Singh 1, 2 , Kausar Mahmood Ansari 1
Affiliation  

The mycotoxin PAT (4-hydroxy-4H-furo[3,2c]pyran-2[6H]-one) is a secondary metabolic product of molds such as Penicillium, Aspergillus, and Byssochlamys species. PAT is a common contaminant of fruit and vegetable based products, most notably apples. Despite PAT's original discovery as an antibiotic, it has come under heavy scrutiny for its potential to impart negative health effects. Studies investigating these health effects have proved its toxic potential. PAT occurrence in the food commodities poses a serious threat and necessitates novel and cost-effective mitigation methods to remove it from food products. It also creates a demand to improve handling and food processing techniques. With this being the case, several studies have been devoted to understanding the key biological and chemical attributes of PAT. While past research has elucidated a great deal, PAT contamination continues to be a challenge for the food industry. Here, we review its influence within the mammalian system, including its regulation, incidences of experimental evidence of PAT toxicity, its interaction with intracellular components, and the effects of PAT induced systemic toxicity on vital organs. Finally, key areas where future PAT research should focus to best control the PAT contamination problem within the food industry have been addressed.

中文翻译:

棒曲霉素霉菌毒素对哺乳动物系统的毒理作用:概述

霉菌毒素PAT(4-羟基-4 H-呋喃[3,2 c ]吡喃-2 [6 H ] -one)是霉菌如青霉菌曲霉比目鱼的次级代谢产物。物种。PAT是水果和蔬菜类产品(尤其是苹果)的常见污染物。尽管PAT最初是作为抗生素发现的,但由于其具有负面健康影响的潜力,因此受到了严格的审查。研究这些健康影响的研究证明了其潜在的毒性。食品中PAT的存在构成了严重的威胁,因此有必要采用新颖且具有成本效益的缓解方法将其从食品中去除。它还提出了改善处理和食品加工技术的需求。在这种情况下,已经进行了一些研究来了解PAT的关键生物学和化学属性。尽管过去的研究已经阐明了很多,但PAT污染仍然是食品行业的挑战。在这里,我们回顾它在哺乳动物系统中的影响,包括其调节,PAT毒性实验证据的发生率,其与细胞内成分的相互作用以及PAT诱导的对全身重要器官的全身毒性的影响。最后,解决了未来PAT研究应重点关注以最佳控制食品行业内PAT污染问题的关键领域。
更新日期:2017-09-04
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