Thanks to the pioneering work done by Professor Hamao Umezawa, bioactive compounds have been used in treatment of several diseases including cancer. In this review, we discuss our work, which focuses on developing new candidates for anti-tumor drugs by screening for bioactive natural compounds in microbial cultures using unique experimental systems. We summarize our recent progress including the following: (1) small-molecule modulators of tumor–stromal cell interactions, (2) inhibitors of three-dimensional spheroid formation of cancer cells, (3) multi-cancer cell panel screening and (4) new experimental animal models for cancer metastasis.

中文翻译：

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鉴定抗肿瘤药物和新生物活性化合物的新方法

由于滨尾梅泽教授所做的开创性工作，生物活性化合物已被用于治疗包括癌症在内的多种疾病。在这篇综述中，我们讨论了我们的工作，该工作侧重于通过使用独特的实验系统筛选微生物培养物中的生物活性天然化合物来开发抗肿瘤药物的新候选人。我们总结了我们最近的进展，包括以下内容：（1）肿瘤与基质细胞相互作用的小分子调节剂；（2）癌细胞三维球体形成的抑制剂；（3）多癌细胞小组筛选和（4）癌症转移的新实验动物模型。