Background Systemic cancer spread is preceded by the establishment of a permissive microenvironment in the target tissue of metastasis - the premetastatic niche. As crucial players in establishment of the pre-metastatic niche, myeloid derived suppressor cells (MDSC) release S100A8/A9, an exosomal protein that contributes to metastasis, angiogenesis, and immune suppression. We report the application of antibody-based single-photon emission computed tomography (SPECT) for detection of S100A8/A9 in vivo as an imaging marker for pre-metastatic tissue priming.

中文翻译：

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肿瘤-免疫相互作用的可视化——S100A8/A9 的目标特异性成像揭示了转移前利基的建立

背景系统性癌症扩散之前是在转移的目标组织中建立了一个允许的微环境 - 转移前的生态位。作为建立转移前生态位的关键参与者，髓源抑制细胞 (MDSC) 释放 S100A8/A9，这是一种有助于转移、血管生成和免疫抑制的外泌体蛋白。我们报告了基于抗体的单光子发射计算机断层扫描 (SPECT)在体内检测 S100A8/A9作为转移前组织启动的成像标记的应用。