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3-D Electrochemical Impedance Spectroscopy Mapping of Arteries to Detect Metabolically Active but Angiographically Invisible Atherosclerotic Lesions
Theranostics ( IF 12.4 ) Pub Date : 2017-06-22 , DOI: 10.7150/thno.19184
René R. Sevag Packard , Yuan Luo , Parinaz Abiri , Nelson Jen , Olcay Aksoy , William M. Suh , Yu-Chong Tai , Tzung K. Hsiai

We designed a novel 6-point electrochemical impedance spectroscopy (EIS) sensor with 15 combinations of permutations for the 3-D mapping and detection of metabolically active atherosclerotic lesions. Two rows of 3 stretchable electrodes circumferentially separated by 120° were mounted on an inflatable balloon for intravascular deployment and endoluminal interrogation. The configuration and 15 permutations of 2-point EIS electrodes allowed for deep arterial penetration via alternating current (AC) to detect varying degrees of lipid burden with distinct impedance profiles (Ω). By virtue of the distinctive impedimetric signature of metabolically active atherosclerotic lesions, a detailed impedance map was acquired, with the 15 EIS permutations uncovering early stages of disease characterized by fatty streak lipid accumulation in the New Zealand White rabbit model of atherosclerosis. Both the equivalent circuit and statistical analyses corroborated the 3-D EIS permutations to detect small, angiographically invisible, lipid-rich lesions, with translational implications for early atherosclerotic disease detection and prevention of acute coronary syndromes or strokes.

中文翻译:

动脉的3-D电化学阻抗谱图,可检测代谢活跃但血管造影不可见的动脉粥样硬化病变

我们设计了一种新颖的六点电化学阻抗谱(EIS)传感器,该传感器具有15种排列组合,用于3-D映射和代谢活性动脉粥样硬化病变的检测。将两排周向间隔为120°的3个可拉伸电极安装在可充气的气球上,以进行血管内展开和腔内审讯。2点EIS电极的配置和15个排列允许通过交流电(AC)穿透深层动脉,从而以不同的阻抗曲线(Ω)检测不同程度的脂质负荷。凭借新陈代谢活跃的动脉粥样硬化病变的独特阻抗学特征,获得了详细的阻抗图,在新西兰白兔动脉粥样硬化模型中,通过15个EIS排列揭示了疾病的早期阶段,其特征是脂肪条纹脂质积累。等效电路和统计分析均证实了3-D EIS排列以检测小的,血管造影上不可见的,富含脂质的病变,对早期动脉粥样硬化疾病的检测和预防急性冠状动脉综合征或中风具有翻译意义。
更新日期:2017-09-04
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