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Electrochemical monitoring of the interaction between anticancer drug and DNA in the presence of antioxidant
Talanta ( IF 6.1 ) Pub Date : 2017-09-01 , DOI: 10.1016/j.talanta.2017.08.089
Merve Muti , Mihrican Muti

The aim of this work is to find out the effect of antioxidant onto the interaction of DNA-anticancer drug, daunorubicin. Daunorubicin (DNR) is an anti-cancer drug which is used for the treatment of certain cancers including the treatment of leukemia. The treatments of patients, who suffer from cancer, become generally complicated if they take some antioxidant-containing supplement during chemotherapy. In this study, the interaction performance between DNR and DNA was investigated both in the presence and absence of antioxidant, caffeic acid, as the first time in the literature. Interaction performances were evaluated by observing both guanine (1.0 V) and DNR (0.5 V) oxidation signal in the same potential window.



中文翻译:

在抗氧化剂存在下电化学监测抗癌药物与DNA之间的相互作用

这项工作的目的是发现抗氧化剂对DNA-抗癌药物柔红霉素的相互作用的影响。柔红霉素(DNR)是一种抗癌药,用于治疗某些癌症,包括治疗白血病。如果患有癌症的患者的治疗在化疗期间服用一些含抗氧化剂的补充剂,通常会变得复杂。在这项研究中,在文献中首次研究了在存在和不存在抗氧化剂,咖啡酸的情况下,DNR与DNA之间的相互作用性能。通过在相同的电位窗口中观察鸟嘌呤(1.0 V)和DNR(0.5 V)氧化信号来评估相互作用性能。

更新日期:2017-09-01
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