Immune privilege is a complex process that protects organs from immune-mediated attack and damage. It is accomplished by a series of cellular barriers that both control immune cell entry and promote the development of tolerogenic immune cells. In this Review, we describe the vascular endothelial and epithelial barriers in organs that are commonly considered to be immune privileged, such as the brain and the eye. We compare these classical barriers with barriers in the intestine, which share features with barriers of immune-privileged organs, such as the capacity to induce tolerance and to protect from external insults. We suggest that when intestinal barriers break down, disruption of other barriers at distant sites can ensue, and this may underlie the development of various neurological, metabolic and intestinal disorders.

中文翻译：

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血管和上皮屏障之间的相互作用介导的器官特异性保护

免疫特权是一个复杂的过程，可以保护器官免受免疫介导的攻击和破坏。它通过控制免疫细胞进入并促进致耐受性免疫细胞发育的一系列细胞屏障来实现。在这篇综述中，我们描述了通常被认为具有免疫优势的器官（如大脑和眼睛）中的血管内皮和上皮屏障。我们将这些经典屏障与肠道屏障进行了比较，肠道屏障与免疫特权器官的屏障具有相同的功能，例如诱导耐受力和保护免受外界侵害的能力。我们建议，当肠壁障碍被打破时，远处的其他壁垒会随之破坏，这可能是各种神经，代谢和肠道疾病发展的基础。