In an era of globalized trade relations where food and pharmaceutical products cross borders effortlessly, consumers face counterfeit and deteriorated products at elevated rates. This paper presents multifunctional, biodegradable hydrogel microparticles that can provide information on the authenticity and the potential deterioration of the tagged food or pharmaceutical formulations. These microparticles integrate spatially patterned authenticity code with two sensors—the first one detects possible presence of pathogenic microbes through monitoring pH while the second one identifies products stored above optimal temperatures via optical monitoring of the microparticle degradation. Particles are synthesized from a biocompatible polymer and a photoinitiator, dextran modified with 2‐hydroxyethylmethacrylate and riboflavin, respectively, using a continuous, high throughput method stop‐flow lithography. The proposed synthesis approach also enables crosslinking with visible light bringing about additional flexibility to flow lithography. Model liquid and solid food and pharmaceutical products are successfully labeled with microparticles and the functionality of the sensors in aqueous solutions is demonstrated.

中文翻译：

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可生物降解的微粒，可同时检测假冒和变质的食用产品

在全球化的贸易关系时代，食品和药品不费吹灰之力就越过了，消费者面对的假冒伪劣产品价格高涨。本文介绍了多功能的，可生物降解的水凝胶微粒，它们可以提供有关带标签食品或药物制剂的真实性和潜在恶化的信息。这些微粒将空间图案化的真实性代码与两个传感器集成在一起-第一个通过监视pH值来检测病原微生物的可能存在，而第二个通过光学监视微粒降解来识别存储在最佳温度以上的产品。颗粒是由生物相容性聚合物和光引发剂合成的，分别由甲基丙烯酸2-羟乙酯和核黄素改性的葡聚糖，使用连续的高通量方法进行止流光刻。所提出的合成方法还使得能够与可见光交联，从而为流式光刻带来了额外的灵活性。液体和固体食品和药品的模型已成功用微粒标记，并演示了传感器在水溶液中的功能。