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Transition-metal-free radical tri-/difluoromethylation of N,N-dialkylhydrazones with sodium sulfinates
Organic Chemistry Frontiers ( IF 5.4 ) Pub Date : 2017-08-24 00:00:00 , DOI: 10.1039/c7qo00635g
Xiao Xu 1, 2, 3, 4, 5 , Feng Liu 1, 2, 3, 4, 5
Affiliation  

A novel protocol is herein described for the preparation of tri-/difluoromethylated N,N-dialkylhydrazones under transition-metal-free conditions and this reaction can be scaled up to the gram level easily. The reaction protocol is operationally simple and performed at ambient temperature, allowing obtaining the desired products in satisfactory yields. The easy-to-handle sodium tri- and difluoromethanesulfinates serve as effective fluoroalkyl radical precursors.

中文翻译:

NN-二烷基hydr与亚磺酸钠的过渡金属自由基三-/二氟甲基化

本文描述了用于在无过渡金属的条件下制备三-/二氟甲基化的NN-二烷基hydr的新颖方案,并且该反应可以容易地放大至克级。该反应方案操作简单并且在环境温度下进行,从而可以令人满意的产率获得所需的产物。易于处理的三氟甲烷亚磺酸钠和二氟甲烷亚磺酸钠可作为有效的氟烷基自由基前体。
更新日期:2017-09-04
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