NAFLD, the hepatic manifestation of the metabolic syndrome, is a multifactorial condition — environmental factors influence an inherited genetic risk. Stender et al. now describe the additive effect of obesity and NAFLD-associated genetic polymorphisms on steatosis, elevated serum alanine aminotransferase levels and cirrhosis, remarkably illustrating the principle of gene–environment interactions.

中文翻译：

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NAFLD：PNPLA3与肥胖：NAFLD中的协同关系

NAFLD是代谢综合征的肝脏表现，是一种多因素疾病-环境因素会影响遗传的遗传风险。Stender等。现在描述肥胖和与NAFLD相关的遗传多态性对脂肪变性，血清丙氨酸氨基转移酶水平升高和肝硬化的累加作用，从而显着说明了基因与环境相互作用的原理。