Recent attempts to analyze human immunodeficiency virus (HIV)-1-induced gene expression changes in astrocytes uncovered a multifunctional oncogene, astrocyte elevated gene-1 (AEG-1). Our previous studies revealed that AEG-1 regulates reactive astrocytes proliferation, migration and inflammation, hallmarks of aging and CNS injury. Moreover, the involvement of AEG-1 in neurodegenerative disorders, such as Huntington's disease and migraine, and its induction in the aged brain suggest a plausible role in regulating overall CNS homeostasis and aging. Therefore, it is important to investigate AEG-1 specifically in aging-associated cognitive decline. In this study, we decipher the common mechanistic links in cancer, aging and HIV-1-associated neurocognitive disorders that likely contribute to AEG-1-based regulation of astrocyte responses and function. Despite AEG-1 incorporation into HIV-1 virions and its induction by HIV-1, tumor necrosis factor-α and interleukin-1β, the specific role(s) of AEG-1 in astrocyte-driven HIV-1 neuropathogenesis are incompletely defined. We propose that AEG-1 plays a central role in a multitude of cellular stress responses involving mitochondria, endoplasmic reticulum and the nucleolus. It is thus important to further investigate AEG-1-based cellular and molecular regulation in order to successfully develop better therapeutic approaches that target AEG-1 to combat cancer, HIV-1 and aging.

中文翻译：

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星形胶质细胞升高基因1（AEG-1）和A（E）金HIV / AIDS-HAND。

分析星形胶质细胞中人类免疫缺陷病毒（HIV）-1诱导的基因表达变化的最新尝试发现了一种多功能癌基因，星形胶质细胞升高基因1（AEG-1）。我们以前的研究表明，AEG-1调节星形胶质细胞的增殖，迁移和炎症，衰老和中枢神经系统损伤的标志。此外，AEG-1参与神经退行性疾病，例如亨廷顿氏病和偏头痛，以及其在衰老大脑中的诱导，提示其在调节总体CNS稳态和衰老中起着合理的作用。因此，重要的是专门研究AEG-1在衰老相关的认知功能减退中。在这项研究中，我们破译了癌症，衰老和HIV-1相关的神经认知障碍中的常见机制联系，这些联系可能有助于基于AEG-1的星形胶质细胞反应和功能调节。尽管将AEG-1掺入HIV-1病毒颗粒并通过HIV-1，肿瘤坏死因子-α和白细胞介素-1β诱导，但AEG-1在星形胶质细胞驱动的HIV-1神经发病机制中的特定作用尚未完全定义。我们建议，AEG-1在涉及线粒体，内质网和核仁的多种细胞应激反应中起核心作用。因此，重要的是，进一步研究基于AEG-1的细胞和分子调控，以成功开发出针对AEG-1的更好的治疗方法，以对抗癌症，HIV-1和衰老。我们建议，AEG-1在涉及线粒体，内质网和核仁的多种细胞应激反应中起核心作用。因此，重要的是，进一步研究基于AEG-1的细胞和分子调控，以成功开发出针对AEG-1的更好的治疗方法，以对抗癌症，HIV-1和衰老。我们建议，AEG-1在涉及线粒体，内质网和核仁的多种细胞应激反应中起核心作用。因此，重要的是，进一步研究基于AEG-1的细胞和分子调控，以成功开发出针对AEG-1的更好的治疗方法，以对抗癌症，HIV-1和衰老。