A novel Et₂Zn/L-proline catalyzed synthesis of symmetrical as well as unsymmetrical buta-1,3-diynes by the cross-coupling of terminal alkynes with 1-bromo alkynes in ethanol solvent was developed in good yields under simple and mild reaction conditions. The use of relatively non toxic and ecofriendly nature of Zn, inexpensive amino acid ligand L-proline and environmentally benign solvent EtOH make this protocol a better alternative for the synthesis of 1,3-diynes. The scope and limitations of this protocol were investigated.

中文翻译：

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乙醇溶剂中新型末端炔与1-溴炔的锌催化Cadiot-Chodkiewicz交叉偶联反应

通过简单和温和的反应，以高收率开发了一种新型的Et ₂ Zn / L-脯氨酸，通过末端炔烃与1-溴炔烃在乙醇溶剂中的交叉偶联，催化对称和不对称的buta-1,3-diynes合成。条件。使用锌的相对无毒且环保的性质，廉价的氨基酸配体L-脯氨酸和对环境无害的溶剂EtOH，使该方案成为合成1,3-二炔的更好选择。研究了该协议的范围和局限性。