Sustained increases in the activity of the sympathetic neural pathways that exit the brain and which increase blood pressure (BP) are a major underlying factor in resistant hypertension. Recently available information on the occurrence of angiotensin II type 2 receptors (AT2Rs) within or adjacent to brain cardiovascular control centers is consistent with findings that stimulation of these receptors lowers BP, particularly during hypertension of neurogenic origin. Until recently brain AT2R had not been considered by many to play a role in the central control of BP. Demonstration of these powerful antihypertensive effects of brain AT2R opens the door to reconsideration of their role in BP regulation, and their consideration as a novel therapeutic avenue for resistant hypertension.

中文翻译：

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血管紧张素 II 2 型受体的中枢介导心血管作用

离开大脑并增加血压 (BP) 的交感神经通路活动的持续增加是顽固性高血压的主要潜在因素。最近关于在脑心血管控制中心内或附近出现血管紧张素 II 2 型受体 (AT2R) 的可用信息与刺激这些受体可降低血压的发现一致，特别是在神经源性高血压期间。直到最近，大脑 AT2R 还没有被许多人认为在 BP 的中枢控制中发挥作用。大脑 AT2R 的这些强大抗高血压作用的证明为重新考虑其在血压调节中的作用打开了大门，并考虑将其作为治疗顽固性高血压的新途径。