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Ligand-Selective Wnt Receptor Complexes in CNS Blood Vessels: RECK and GPR124 Plugged In.
Neuron ( IF 16.2 ) Pub Date : 2017-Aug-30 , DOI: 10.1016/j.neuron.2017.08.026
Harald J. Junge

CNS angiogenesis and blood-brain barrier integrity are controlled by the canonical Wnt pathway. In this issue of Neuron, Cho et al. (2017) use advanced mouse genetics and biochemical experiments to unravel the ligand-specific association of membrane proteins GPR124 and RECK with Wnt receptor complexes.

中文翻译:

CNS血管中的配体选择性Wnt受体复合物:已插入RECK和GPR124。

中枢神经系统的血管生成和血脑屏障的完整性是由规范的Wnt途径控制的。在本期《神经元》中,Cho等人。(2017)使用先进的小鼠遗传学和生化实验揭示了膜蛋白GPR124和RECK与Wnt受体复合物的配体特异性结合。
更新日期:2017-08-31
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