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Toward Greater Implementation of the Exposome Research Paradigm within Environmental Epidemiology
Annual Review of Public Health ( IF 20.8 ) Pub Date : 2017-04-06 00:00:00 , DOI: 10.1146/annurev-publhealth-082516-012750
Jeanette A. Stingone 1 , Germaine M. Buck Louis 2 , Shoji F. Nakayama 3 , Roel C.H. Vermeulen 4 , Richard K. Kwok 5 , Yuxia Cui 6 , David M. Balshaw 6 , Susan L. Teitelbaum 1
Affiliation  

Investigating a single environmental exposure in isolation does not reflect the actual human exposure circumstance nor does it capture the multifactorial etiology of health and disease. The exposome, defined as the totality of environmental exposures from conception onward, may advance our understanding of environmental contributors to disease by more fully assessing the multitude of human exposures across the life course. Implementation into studies of human health has been limited, in part owing to theoretical and practical challenges including a lack of infrastructure to support comprehensive exposure assessment, difficulty in differentiating physiologic variation from environmentally induced changes, and the need for study designs and analytic methods that accommodate specific aspects of the exposome, such as high-dimensional exposure data and multiple windows of susceptibility. Recommendations for greater data sharing and coordination, methods development, and acknowledgment and minimization of multiple types of measurement error are offered to encourage researchers to embark on exposome research to promote the environmental health and well-being of all populations.

中文翻译:


争取在环境流行病学中更好地实施“流行研究”范式

孤立地调查单个环境暴露并不能反映实际的人类暴露情况,也不能反映健康和疾病的多因素病因。从概念开始就定义为暴露于环境中的总暴露量,可以通过更全面地评估整个生命过程中的人类暴露量来增进我们对疾病的环境贡献者的理解。人体健康研究的实施受到限制,部分原因是由于理论和实践上的挑战,包括缺乏支持全面暴露评估的基础设施,难以将生理变化与环境诱发的变化区分开来,以及需要适应研究的设计和分析方法暴露的特定方面,例如高维曝光数据和多个磁化率窗口。提供了有关加强数据共享和协调,方法开发以及承认和最小化多种类型的测量误差的建议,以鼓励研究人员着手进行暴露研究,以促进所有人的环境健康和福祉。

更新日期:2017-04-06
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