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Innovative Approaches to Improve Anti-Infective Vaccine Efficacy
Annual Review of Pharmacology and Toxicology ( IF 12.5 ) Pub Date : 2017-01-06 00:00:00 , DOI: 10.1146/annurev-pharmtox-010716-104718
Michael R. Yeaman 1, 2, 3, 4 , John P. Hennessey 5
Affiliation  

Safe and efficacious vaccines are arguably the most successful medical interventions of all time. Yet the ongoing discovery of new pathogens, along with emergence of antibiotic-resistant pathogens and a burgeoning population at risk of such infections, imposes unprecedented public health challenges. To meet these challenges, innovative strategies to discover and develop new or improved anti-infective vaccines are necessary. These approaches must intersect the most meaningful insights into protective immunity and advanced technologies with capabilities to deliver immunogens for optimal immune protection. This goal is considered through several recent advances in host-pathogen relationships, conceptual strides in vaccinology, and emerging technologies. Given a clear and growing risk of pandemic disease should the threat of infection go unmet, developing vaccines that optimize protective immunity against high-priority and antibiotic-resistant pathogens represents an urgent and unifying imperative.

中文翻译:


提高抗感染疫苗功效的创新方法

安全有效的疫苗可以说是有史以来最成功的医学干预措施。然而,新病原体的不断发现,以及抗生素抗性病原体的出现以及面临此类感染风险的新兴人群,给公共卫生带来了前所未有的挑战。为了应对这些挑战,发现和开发新的或改良的抗感染疫苗的创新策略是必要的。这些方法必须与对保护性免疫力和先进技术的最有意义的见解相交,先进的技术应具有提供免疫原以实现最佳免疫保护的能力。通过在宿主-病原体关系方面的一些最新进展,疫苗学的概念性进步以及新兴技术,可以考虑该目标。如果大流行病的危险性正在明显上升,那么如果不能完全消除感染的威胁,

更新日期:2017-01-06
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