A series of twelve novel compounds, analogues of antiviral agent MDL-860 were synthesized and their antiviral activity was evaluated in vitro against enteroviruses poliovirus 1 (PV1), Coxsackieviruses B1 (CVB1) and Coxsackieviruses B3 (CVB3). Compounds 14, 24 and 25 manifested strong antiviral effects against CVB1 and PV1 (SI values of 405 and 118 for CVB1 and PV1 respectively). In contrast to the wide anti-enteroviral activity of MDL-860, these three compounds were inactive against CVB3. Compounds 14, 24 and 25 along with MDL-860 were tested in vivo in mice infected with CVB1. Marked protective effects of compounds 14 and 24 were established, PI values of 50% and 33.3%, respectively. In addition, almost all of the tested compounds manifested very low toxicity.

合成了一系列十二种新化合物，即抗病毒剂MDL-860的类似物，并在体外评估了它们对肠道病毒脊髓灰质炎病毒1（PV1），柯萨奇病毒B1（CVB1）和柯萨奇病毒B3（CVB3）的抗病毒活性。化合物14，24度25表现强的抗病毒抗CVB1和PV1（和分别的405 SI值118，用于CVB1和PV1）的影响。与MDL-860广泛的抗肠病毒活性相反，这三种化合物对CVB3没有活性。化合物14，24和25与MDL-860沿着中测试体内感染CVB1小鼠。化合物的明显保护作用14分别建立了24个和24个，PI值分别为50％和33.3％。另外，几乎所有测试的化合物都表现出非常低的毒性。