UK Biobank is among the world's largest repositories for phenotypic and genotypic information in individuals of European ancestry. We performed a genome-wide association study in UK Biobank testing ∼9 million DNA sequence variants for association with coronary artery disease (4,831 cases and 115,455 controls) and carried out meta-analysis with previously published results. We identified 15 new loci, bringing the total number of loci associated with coronary artery disease to 95 at the time of analysis. Phenome-wide association scanning showed that CCDC92 likely affects coronary artery disease through insulin resistance pathways, whereas experimental analysis suggests that ARHGEF26 influences the transendothelial migration of leukocytes.

中文翻译：

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英国生物银行的遗传分析将胰岛素抵抗和跨内皮迁移途径与冠状动脉疾病联系起来。

UK Biobank 是世界上最大的欧洲血统个体表型和基因型信息库之一。我们在 UK Biobank 进行了一项全基因组关联研究，测试了约 900 万个 DNA 序列变异与冠状动脉疾病的关联（4,831 例病例和 115,455 例对照），并对先前发表的结果进行了荟萃分析。我们确定了 15 个新位点，使分析时与冠状动脉疾病相关的位点总数达到 95 个。全表型关联扫描显示 CCDC92 可能通过胰岛素抵抗途径影响冠状动脉疾病，而实验分析表明 ARHGEF26 影响白细胞的跨内皮迁移。