Cellular senescence, a cell-autonomous growth arrest program, also executes pleiotropic non-cell-autonomous activities through the senescence-associated secretory phenotype (SASP). The innate cGAS-STING DNA-sensing pathway is now shown to regulate senescence by recognizing cytosolic DNA and inducing SASP factors, uncovering an unexpected link between these two previously unrelated pathways.

中文翻译：

---

DNA感应衰老。

细胞衰老是一种细胞自主的生长停滞程序，它还通过衰老相关的分泌表型（SASP）执行多效性非细胞自主活动。现在显示，固有的cGAS-STING DNA传感途径通过识别胞质DNA和诱导SASP因子来调节衰老，从而揭示了这两个先前不相关的途径之间的意外联系。