Induced pluripotent stem cells derived from aged donors (A-iPSCs) usually show genomic instability that affects their utility and raises concerns about their safety. Now, a study highlights the importance of ZSCAN10-dependent recovery of glutathione-ROS homeostasis in counteracting the genomic defects in A-iPSCs.

中文翻译：

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ZSCAN10和ROS在复兴道路上取得了卓有成效的联系。

衍生自老年供体（A-iPSC）的多能干细胞通常显示出基因组不稳定，从而影响其效用并引起对其安全性的担忧。现在，一项研究强调了ZSCAN10依赖的谷胱甘肽-ROS稳态恢复在抵消A-iPSCs基因组缺陷中的重要性。