Cancer treatments often focus on killing tumour cells through apoptosis, which is thought to typically require mitochondrial outer membrane permeabilization (MOMP) and subsequent caspase activation. A study now shows that MOMP can trigger TNF-dependent, but caspase-independent cell death, suggesting a different approach to improve cancer therapy.

中文翻译：

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一种与胱天蛋白酶无关的杀死癌细胞的方法。

癌症治疗通常集中于通过凋亡杀死肿瘤细胞，据认为这通常需要线粒体外膜通透性（MOMP）和随后的半胱天冬酶激活。现在的一项研究表明，MOMP可以触发TNF依赖性但不依赖caspase的细胞死亡，这提示了改善癌症治疗的另一种方法。