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Absence of Selection for Quantum Coherence in the Fenna–Matthews–Olson Complex: A Combined Evolutionary and Excitonic Study
ACS Central Science ( IF 18.2 ) Pub Date : 2017-08-30 00:00:00 , DOI: 10.1021/acscentsci.7b00269
Stéphanie Valleau 1 , Romain A. Studer 2 , Florian Häse 1 , Christoph Kreisbeck 1 , Rafael G. Saer 3 , Robert E. Blankenship 3 , Eugene I. Shakhnovich 1 , Alán Aspuru-Guzik 1, 4
Affiliation  

We present a study on the evolution of the Fenna–Matthews–Olson bacterial photosynthetic pigment–protein complex. This protein complex functions as an antenna. It transports absorbed photons—excitons—to a reaction center where photosynthetic reactions initiate. The efficiency of exciton transport is therefore fundamental for the photosynthetic bacterium’s survival. We have reconstructed an ancestor of the complex to establish whether coherence in the exciton transport was selected for or optimized over time. We have also investigated the role of optimizing free energy variation upon folding in evolution. We studied whether mutations which connect the ancestor to current day species were stabilizing or destabilizing from a thermodynamic viewpoint. From this study, we established that most of these mutations were thermodynamically neutral. Furthermore, we did not see a large change in exciton transport efficiency or coherence, and thus our results predict that exciton coherence was not specifically selected for.

中文翻译:

费纳-马修斯-奥尔森复合体中量子相干选择的缺失:进化与激子研究

我们对费纳-马修斯-奥尔森细菌的光合色素-蛋白质复合物的进化进行了研究。这种蛋白质复合物起着天线的作用。它将吸收的光子(激子)传输到反应中心,在此发生光合作用反应。因此,激子运输的效率对于光合细菌的生存至关重要。我们已经重建了复合体的祖先,以确定是否选择了激子运输中的相干性或随着时间的流逝优化了激子运输中的相干性。我们还研究了在折叠过程中优化自由能变化的作用。我们从热力学的角度研究了将祖先连接到当今物种的突变是稳定的还是不稳定的。通过这项研究,我们确定了大多数突变是热力学中性的。
更新日期:2017-08-30
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