Beyond editing to writing large genomes

Nature Reviews Genetics, Published online: 30 August 2017; doi:10.1038/nrg.2017.59

Advances in genome sequencing, editing and synthetic biology have enhanced the feasibility of large-scale genome engineering, termed genome writing. In this Opinion article, Chari and Church discuss the strengths and limitations of diverse strategies for genome writing, including extensively modifying existing genomes versus synthesizing genomes de novo, and they provide future visions for writing large genomes.

中文翻译：

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除了编辑之外，还可以编写大型基因组

除了编辑之外，还可以编写大型基因组

《自然评论遗传学》（Nature Reviews Genetics），在线发布：2017年8月30日; doi：10.1038 / nrg.2017.59

基因组测序，编辑和合成生物学的进步增强了大规模基因组工程（称为基因组编写）的可行性。在这篇观点文章中，Chari和Church讨论了基因组编写各种策略的优点和局限性，包括广泛修改现有基因组与从头合成基因组，它们为编写大型基因组提供了未来的愿景。