In this review, supramolecular catalysis refers to the integration of the catalytic process with molecular self-assembly driven by noncovalent interactions, and dynamic assemblies are the assemblies that form and dissipate reversibly. Cells extensively employ supramolecular catalysis and dynamic assemblies for controlling their complex functions. The dynamic generation of supramolecular assemblies of small molecules has made considerable progress in the last decade, though the disassembly processes remain underexplored. Here, we discuss the regulation of dynamic assemblies via self-assembly and disassembly processes for therapeutics and diagnostics. We first briefly introduce the self-assembly and disassembly processes in the context of cells, which provide the rationale for designing approaches to control the assemblies. Then, we describe recent advances in designing and regulating the self-assembly and disassembly of small molecules, especially for molecular imaging and anticancer therapeutics. Finally, we provide a perspective on future directions of the research on supramolecular catalysis and dynamic assemblies for medicine.

中文翻译：

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医学超分子催化和动态组装

在本综述中，超分子催化是指催化过程与非共价相互作用驱动的分子自组装的整合，动态组装是可逆地形成和消散的组装。细胞广泛采用超分子催化和动态组装来控制其复杂功能。小分子超分子组装的动态生成在过去十年中取得了相当大的进展，尽管拆卸过程仍未得到充分探索。在这里，我们讨论通过自组装和拆卸过程对动态组装的调节，用于治疗和诊断。我们首先简要介绍细胞背景下的自组装和拆卸过程，这为设计控制组装的方法提供了基本原理。然后，我们描述了设计和调节小分子自组装和分解的最新进展，特别是在分子成像和抗癌治疗方面。最后，我们对医学超分子催化和动态组装的研究未来方向进行了展望。