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Polymer‐Based Surfaces Designed to Reduce Biofilm Formation: From Antimicrobial Polymers to Strategies for Long‐Term Applications
Macromolecular Rapid Communications ( IF 4.6 ) Pub Date : 2017-08-28 , DOI: 10.1002/marc.201700216
Esther K Riga 1 , Maria Vöhringer 1 , Vania Tanda Widyaya 1 , Karen Lienkamp 1
Affiliation  

Contact‐active antimicrobial polymer surfaces bear cationic charges and kill or deactivate bacteria by interaction with the negatively charged parts of their cell envelope (lipopolysaccharides, peptidoglycan, and membrane lipids). The exact mechanism of this interaction is still under debate. While cationic antimicrobial polymer surfaces can be very useful for short‐term applications, they lose their activity once they are contaminated by a sufficiently thick layer of adhering biomolecules or bacterial cell debris. This layer shields incoming bacteria from the antimicrobially active cationic surface moieties. Besides discussing antimicrobial surfaces, this feature article focuses on recent strategies that were developed to overcome the contamination problem. This includes bifunctional materials with simultaneously presented antimicrobial and protein‐repellent moieties; polymer surfaces that can be switched from an antimicrobial, cell‐attractive to a cell‐repellent state; polymer surfaces that can be regenerated by enzyme action; degradable antimicrobial polymers; and antimicrobial polymer surfaces with removable top layers.

中文翻译:

旨在减少生物膜形成的聚合物表面:从抗菌聚合物到长期应用策略

接触活性抗菌聚合物表面带有阳离子电荷,通过与细菌细胞包膜带负电的部分(脂多糖、肽聚糖和膜脂)相互作用来杀死或灭活细菌。这种相互作用的确切机制仍在争论中。虽然阳离子抗菌聚合物表面对于短期应用非常有用,但一旦被足够厚的粘附生物分子或细菌细胞碎片层污染,它们就会失去活性。该层可保护细菌免受抗菌活性阳离子表面部分的侵害。除了讨论抗菌表面之外,这篇专题文章还重点介绍了为克服污染问题而开发的最新策略。这包括同时具有抗菌和蛋白质排斥部分的双功能材料;聚合物表面可以从抗菌、细胞吸引状态转变为细胞排斥状态;可通过酶作用再生的聚合物表面;可降解抗菌聚合物;以及具有可拆卸顶层的抗菌聚合物表面。
更新日期:2017-08-28
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