当前位置: X-MOL 学术J. Antibiot. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Trichopeptides A and B, trichocyclodipeptides A–C, new peptides from the ascomycete fungus Stagonospora trichophoricola
The Journal of Antibiotics ( IF 3.3 ) Pub Date : 2017-07-05 , DOI: 10.1038/ja.2017.76
Zhengkun Chen , Xiuli Xu , Jinwei Ren , Wenzhao Wang , Xingzhong Liu , Erwei Li

Trichopeptides A (1) and B (2), new linear tetrapeptide and tripeptide, respectively, and three new diketopiperazines trichocyclodipeptides A–C (35) were isolated from the fermentation of the ascomycete fungus Stagonospora trichophoricola, a fungus isolated from the soil sample surrounding the fruiting body of Ophiocordyceps sinensis in Maqin Country, Qinghai Province, People’s Republic of China. Their structures were primarily elucidated by interpretation of NMR and MS experiments. The absolute configurations of 15 were assigned through Marfey’s method on their acid hydrolyzates. Compound 3 showed antifungal activity against Candida albicans with the IC50 and MIC values of 22 and 90μgml−1, respectively.

中文翻译:

Trichopeptides A和B,trichocyclodepteptes A–C,来自子囊真菌Stagonospora trichophoricola的新肽

Trichopeptides A(1)和B(2),分别新的线性四肽和三肽,和三个新二酮哌嗪trichocyclodipeptides A-C(3 - 5)购自子囊菌真菌Stagonospora trichophoricola发酵分离,真菌从土壤中分离中华人民共和国青海省玛沁县中华phi蛇子实体周围的样本。主要通过对NMR和MS实验的解释来阐明它们的结构。的绝对构型1 - 5是通过的Marfey法对它们的酸水解物进行分配。化合物3通过IC对白念珠菌显示出抗真菌活性50个的22和90和MIC值微克毫升-1分别。
更新日期:2017-08-28
down
wechat
bug