The mucosal inflammatory response induced by Salmonella serovar Typhimurium creates a favorable niche for this gut pathogen. Conventional wisdom holds that S. Typhimurium undergoes an incomplete tricarboxylic acid (TCA) cycle in the anaerobic mammalian gut. One change during S. Typhimurium-induced inflammation is the production of oxidized compounds by infiltrating neutrophils. We show that inflammation-derived electron acceptors induce a complete, oxidative TCA cycle in S. Typhimurium, allowing the bacteria to compete with the microbiota for colonization. A complete TCA cycle facilitates utilization of the microbiota-derived fermentation product succinate as a carbon source. S. Typhimurium succinate utilization genes contribute to efficient colonization in conventionally raised mice, but provide no growth advantage in germ-free mice. Mono-association of gnotobiotic mice with Bacteroides, a major succinate producer, restores succinate utilization in S. Typhimurium. Thus, oxidative central metabolism enables S. Typhimurium to utilize a variety of carbon sources, including microbiota-derived succinate.

鼠伤寒沙门氏菌引起的黏膜炎症反应为这种肠道病原体创造了有利的生态环境。传统观点认为S。鼠伤寒在厌氧哺乳动物肠道中经历不完全的三羧酸 (TCA) 循环。S期间的一次更改。鼠伤寒引起的炎症是通过浸润嗜中性粒细胞产生氧化化合物。我们表明炎症衍生的电子受体在S中诱导完整的氧化 TCA 循环。Typhimurium，允许细菌与微生物群竞争定植。完整的 TCA 循环有助于利用微生物群衍生的发酵产物琥珀酸盐作为碳源。小号. Typhimurium succinate 利用基因有助于在常规饲养的小鼠中有效定植，但在无菌小鼠中没有提供生长优势。拟杆菌属（一种主要的琥珀酸生产者）与拟杆菌属（ Bacteroides ）的单一关联可恢复S. 鼠伤寒菌。因此，氧化中枢代谢使S 成为可能。Typhimurium 利用多种碳源，包括微生物群衍生的琥珀酸盐。