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Zinc oxide nanoparticles: a promising nanomaterial for biomedical applications
Drug Discovery Today ( IF 7.4 ) Pub Date : 2017-08-25 , DOI: 10.1016/j.drudis.2017.08.006
Pawan K. Mishra , Harshita Mishra , Adam Ekielski , Sushama Talegaonkar , Bhuvaneshwar Vaidya

Zinc oxide (ZnO) nanoparticles (NPs) are a promising platform for use in biomedical research, especially given their anticancer and antimicrobial activities. These activities are associated with the ability of ZnO NPs to generate reactive oxygen species (ROS) and induce apoptosis. In addition, ZnO NPs have been successfully exploited as drug carriers for loading and transporting drugs to target sites, thereby reducing unwanted toxicity and off-target effects, and resulting in amplified synergistic effects. Here, we discuss the synthesis and biomedical applications of ZnO NPs.



中文翻译:

氧化锌纳米颗粒:一种有前途的生物医学应用纳米材料

氧化锌(ZnO)纳米颗粒(NPs)是用于生物医学研究的有前途的平台,特别是考虑到它们的抗癌和抗菌活性。这些活性与ZnO NPs产生活性氧(ROS)并诱导细胞凋亡的能力有关。此外,ZnO NP已成功地用作药物载体,用于将药物装载和运输至目标部位,从而减少了有害的毒性和脱靶效应,并产生了协同效应。在这里,我们讨论了ZnO NPs的合成和生物医学应用。

更新日期:2017-08-25
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