Abstract

The electrocyclic reaction is one of the most powerful tools for the construction of complex polycyclic scaffolds in a highly stereocontrolled fashion. In this review, recent advances in its application in the total synthesis of representative natural products are discussed, with the aim of providing a complement to existing reviews.

1 Introduction

2 4π Electrocyclization

2.1 Neutral 4π Electrocyclization

2.2 Cationic 4π Electrocyclization

3 6π Electrocyclization

3.1 All-Carbon 6π Electrocyclization

3.2 Oxa-6π Electrocyclization

3.3 Aza-6π Electrocyclization

3.4 Retro-6π Electrocyclization

4 8π Electrocyclization

5 Conclusion and Outlook

The electrocyclic reaction is one of the most powerful tools for the construction of complex polycyclic scaffolds in a highly stereocontrolled fashion. In this review, recent advances in its application in the total synthesis of representative natural products are discussed, with the aim of providing a complement to existing reviews.

1 Introduction

2 4π Electrocyclization

2.1 Neutral 4π Electrocyclization

2.2 Cationic 4π Electrocyclization

3 6π Electrocyclization

3.1 All-Carbon 6π Electrocyclization

3.2 Oxa-6π Electrocyclization

3.3 Aza-6π Electrocyclization

3.4 Retro-6π Electrocyclization

4 8π Electrocyclization

5 Conclusion and Outlook

中文翻译：

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电环反应在复杂天然产物合成中的应用新进展

摘要

电环反应是以高度立体可控的方式构建复杂的多环支架的最强大工具之一。在这篇综述中，讨论了其在代表性天然产物的全合成中应用的最新进展，目的是对现有综述进行补充。

1引言

24π电环化

2.1中性4π电环化

2.2阳离子4π电环化

36π电环化

3.1全碳6π电环化

3.2Oxa-6π电环化

3.3Aza-6π电环化

3.4Retro-6π电环化

48π电环化

5结论与展望

电环反应是以高度立体可控的方式构建复杂的多环支架的最强大工具之一。在这篇综述中，讨论了其在代表性天然产物的全合成中应用的最新进展，目的是对现有综述进行补充。

1引言

24π电环化

2.1中性4π电环化

2.2阳离子4π电环化

36π电环化

3.1全碳6π电环化

3.2Oxa-6π电环化

3.3Aza-6π电环化

3.4Retro-6π电环化

48π电环化

5结论与展望