当前位置: X-MOL 学术Nat. Rev. Cancer › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Targeting autophagy in cancer
Nature Reviews Cancer ( IF 78.5 ) Pub Date : 2017-07-28 00:00:00 , DOI: 10.1038/nrc.2017.53
Jean M. Mulcahy Levy , Christina G. Towers , Andrew Thorburn

Autophagy is a mechanism by which cellular material is delivered to lysosomes for degradation, leading to the basal turnover of cell components and providing energy and macromolecular precursors. Autophagy has opposing, context-dependent roles in cancer, and interventions to both stimulate and inhibit autophagy have been proposed as cancer therapies. This has led to the therapeutic targeting of autophagy in cancer to be sometimes viewed as controversial. In this Review, we suggest a way forwards for the effective targeting of autophagy by understanding the context-dependent roles of autophagy and by capitalizing on modern approaches to clinical trial design.

中文翻译:

靶向癌症中的自噬

自噬是一种机制,通过该机制细胞材料被递送至溶酶体进行降解,从而导致细胞成分的基础周转并提供能量和大分子前体。自噬在癌症中具有相反的,取决于情境的作用,并且已经提出了刺激和抑制自噬的干预措施作为癌症疗法。这导致癌症中自噬的治疗靶向有时被认为是有争议的。在本综述中,我们通过了解自噬的背景相关作用并利用现代的临床试验设计方法,为有效地靶向自噬提出了一条前进的道路。
更新日期:2017-08-24
down
wechat
bug