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Regulatory Innate Lymphoid Cells Control Innate Intestinal Inflammation.
Cell ( IF 64.5 ) Pub Date : 2017-Sep-21 , DOI: 10.1016/j.cell.2017.07.027
Shuo Wang , Pengyan Xia , Yi Chen , Yuan Qu , Zhen Xiong , Buqing Ye , Ying Du , Yong Tian , Zhinan Yin , Zhiheng Xu , Zusen Fan

An emerging family of innate lymphoid cells (termed ILCs) has an essential role in the initiation and regulation of inflammation. However, it is still unclear how ILCs are regulated in the duration of intestinal inflammation. Here, we identify a regulatory subpopulation of ILCs (called ILCregs) that exists in the gut and harbors a unique gene identity that is distinct from that of ILCs or regulatory T cells (Tregs). During inflammatory stimulation, ILCregs can be induced in the intestine and suppress the activation of ILC1s and ILC3s via secretion of IL-10, leading to protection against innate intestinal inflammation. Moreover, TGF-β1 is induced by ILCregs during the innate intestinal inflammation, and autocrine TGF-β1 sustains the maintenance and expansion of ILCregs. Therefore, ILCregs play an inhibitory role in the innate immune response, favoring the resolution of intestinal inflammation.

中文翻译:

调节性先天淋巴细胞可控制先天性肠道炎症。

新兴的先天性淋巴样细胞家族(称为ILC)在炎症的引发和调节中起着至关重要的作用。然而,目前尚不清楚肠炎症期间ILC如何被调节。在这里,我们确定了肠道中存在的ILC的调节亚群(称为ILCregs),并具有不同于ILC或调节性T细胞(Tregs)的独特基因身份。在炎症刺激过程中,ILCregs可以在肠道中被诱导,并通过分泌IL-10抑制ILC1s和ILC3s的激活,从而导致针对先天性肠道炎症的保护作用。此外,在先天肠道炎症期间,ILCregs诱导TGF-β1,而自分泌TGF-β1维持ILCregs的维持和扩增。因此,ILCregs在先天免疫反应中起抑制作用,
更新日期:2017-08-24
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