Tumor cells are known for their propensity to proliferate uncontrollably and generate multitudes of metastatic masses at the advanced stages of cancer. During this progression, tumor cells switch their energy source from mitochondrial oxidative phosphorylation to a glucose-dependent glycolytic pathway, despite the availability of oxygen. Consequently, tumor cells increase their metabolic rates as well as glucose uptake to maintain their proliferation. This atypical metabolic phenomenon is known as the Warburg effect, which has been recognized as a hallmark of cancer and serves as a promising target for diagnosis and therapy of cancer. In this review, we summarize the current advances toward the development of glucose-derived therapeutic and diagnostic agents (theranostics) of cancer.

众所周知，肿瘤细胞倾向于在癌症晚期阶段不受控制地增殖并产生大量转移性肿块。在此进展过程中，尽管有氧气可用，肿瘤细胞仍将其能量源从线粒体氧化磷酸化转换为葡萄糖依赖性糖酵解途径。因此，肿瘤细胞增加其代谢率以及葡萄糖摄取以维持其增殖。这种非典型的新陈代谢现象被称为Warburg效应，已被公认是癌症的标志，并成为癌症诊断和治疗的有希望的靶标。在这篇综述中，我们总结了目前发展为葡萄糖的癌症治疗和诊断剂（热疗）的最新进展。